Systems-based Interactome Analysis for Dang-gui’s Hematopoiesis Effect: Cross-talking Agents Regulate Cell Proliferation towards Hemopoiesis

 

 

 

Systems-based interactome network for Dang-gui’s hematopoiesis effect

 

 

 

 

 

Biology systems affected by proteins targeted by Dabng-gui

Biology System

Expected Ratio

Actual Ratio

Fold

Skeletal

0.000861

0.003285

3.81

Circulatory

0.010458

0.037882

3.62

Nervous

0.002551

0.008623

3.38

Urinary

0.003633

0.011397

3.13

Lymphatic

0.007852

0.023512

2.99

Endocrine

0.000116

0.000307

2.64

Respiratory

0.003214

0.008317

2.58

Reproductive

0.011877

0.026182

2.20

Digestive

0.000961

0.001950

2.02

 

 

PANTHER Biological process and Reactome pathway of targeted PPI proteins from interactome network for Dang-gui.

 

Pathway name

p value

Metabolism

9.7E-25

Signal Transduction

9.9E-16

Gene Expression

5.3E-08

Immune System

2.4E-07

Metabolism of proteins

2.5E-07

Disease

2.4E-06

Cell Cycle

1.9E-05

Transmembrane transport of small molecules

4.9E-05

Extracellular matrix organization

5.1E-05

 

 

 

PANTHER overrepresentation biological processes in universal interactome network for Dang-gui

 

 

 

 

 

 

Regulated cell proliferation towards hemopoiesis by Dang-gui