The Osteoporosis Biobank is a resource for osteoporosis-related research, with the aim of improving the diagnosis, prevention and treatment of postmenopausal or senile osteoporosis (Figure 1). This biobank is managed by the Hong Kong Baptist University team utilizing a biobank information system in the Science Park of Hong Kong. The Osteoporosis Biobank was set up by the Hong Kong Baptist University in collaboration with The University of Hong Kong and Shenzhen People’s Hospital in 2011. Up to now, the Osteoporosis Biobank has collected more than 13,000 bio-specimens from postmenopausal or senile osteoporosis patients with or without fragile fractures (Figure 2), including the blood, urine, stool and bone tissues. This Biobank is essential for helping to figure out the novel precision therapeutic strategy for osteoporosis based on the large population data from southern China.



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Figure 1. General view of the Osteoporosis Biobank.



Detailed information about the biobank is as follows:


1. Bio-specimens in Osteoporosis Biobank:

In the Osteoporosis Biobank, the bio-specimen collection, delivery and storage strictly follows the instructions of UK Biobank. Every year, the Osteoporosis Biobank collects around 2000 bio-specimens from postmenopausal or senile osteoporosis patients with or without fragile fractures. Currently, more than 13,000 bio-specimens from have been collected for the Osteoporosis Biobank (Figure 2). The type of bio-specimens in the Osteoporosis Biobank includes blood, urine, stool and bone tissues. Blood and urine bio-specimens were taken from osteoporosis patients. Bone tissues were taken from patients with osteoporosis during orthopedic surgery (Figure 3). The bio-specimen collection was conducted in accordance with the ethical principles of the Declaration of Helsinki and Good Clinical Practice guidelines and was approved by the Ethics Committee in Institute of Basic Research in Clinical medicine(CACMS). Informed consent was obtained from all patients. All the bio-specimens are immediately stored into Osteoporosis Biobank after collection from clinic sites.



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Figure 2 Bio-specimens’ collection per year.



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Figure 3 Collections of bio-specimens.



 2. Infrastructure for Osteoporosis Biobank:

The infrastructure of the Osteoporosis Biobank incudes three parts: the bio-specimen storage system (Thermo Scientific Forma PEEK ULT Freezer 88700V, for storage of bio-specimen), the biobank information system (Dell PowerEdge R850, for management of bio-specimen information), and the bio-specimen identification system (BP-IP300 and Honeywell Hyperion 1300g Scanner, for coding and decoding of bio-specimen) (Figure 1).

 

 

3. Information system for Osteoporosis Biobank:

The biobank information system is the core part of the Osteoporosis Biobank. It monitors the status of the biobank, manages the storage of bio-specimens and records the information of bio-specimens. The information for each bio-specimen includes the data of both the bio-specimen and its origin, such as patient feature, tissue source, morbid state, collection date, etc. This system is built up by the Hong Kong Baptist University team and now locates in the Science Park of Hong Kong (Figure 4).



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Figure 4 Location of the biobank information system.




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