Note: IBTS academic staffs’ name are highlighted with blue.

 

 

 

Published Conference Abstract in 2015

 

1.         

Guo B, Lu A, Zhang B, Zhang G. Therapeutic inhibition of miR-214 by   (AspSerSer)6-liposome encapsulating antagomir-214 in osteoblast cells for   promoting bone formation in aged osteoporotic rats. 2015 Orthopaedic Research   Society (ORS) annual meeting, Las Vegas, March 28-31, 2015.

2.         

Liang C, Guo B, Wu H, Zhang L, Lu A, Zhang G. Aptamer-functionalized delivery system for osteogenic siRNAs to   achieve osteoblast-specific RNA interference for bone anabolic therapy. 2015   Orthopaedic Research Society (ORS) annual meeting, Las Vegas, March 28-31,   2015.

3.         

Lv C, Liu J, Guo B, Li D, Liang C,   Zhang B, Pan X, Zhang L, Lu A, Zhang G. Increased CKIP-1 expression and   decreased phosphorylated Smad1/5 within osteoblasts during bone formation   reduction in glucocorticoid-induced osteoporotic rats. 2015 Orthopaedic   Research Society (ORS) annual meeting, Las Vegas, March 28-31, 2015.

4.         

Li D, Liu J, Guo B, Liang C, Dang L,   He X, Liang Z, Lu A, Zhang G. Exosome-encapsulated miR-214   secreted from osteoclast to inhibit osteoblastic activity. 2015 Orthopaedic   Research Society (ORS) annual meeting, Las Vegas, March 28-31, 2015.

5.         

Liu J, Guo B, Li D, Liang C, Dang L,   He X, Zhang B, Pan X, Zhang L, Lu A, Zhang G. Increased CKIP-1 within osteoblast   suppress BMP signaling to inhibit bone formation during aging. 2015   Orthopaedic Research Society (ORS) annual meeting, Las Vegas, March 28-31,   2015.

6.         

Dang L, Guo B, Li D, Liu J, Liang C,   He X, Wu H, Yang Z, Liang Z, Lu A, Zhang G. Adelivery system approach bone   resorption surface for specifically targeting osteoclasts in vivo. 2015   Orthopaedic Research Society (ORS) annual meeting, Las Vegas, March 28-31,   2015. 

 


Published Conference Abstract in 2014

 

1.         

Junzhe Huang, Jun Lu, Biao Liu, Xiaojuan He, Ge Zhang, Aiping Lu. Fibroblast   like synoviocytes (FLS)-specific aptamer facilitates the   conjugated-triptolide selectively targeting rheumatic joints with less   exposure to liver in rodents. 8th European Workshop on Immune-Mediated   Inflammatory Diseases. Funchal - Madeira, Portugal. November 5-7, 2014.

2.         

Xiaojuan He, Kang Zheng, Yukun Zhao, Baosheng Guo, Jin Liu, Ge Zhang, Aiping Lu. Aberrant overexpression of CKIP-1 in osteoblast correlated with progressive   bone erosion and decreased bone formation in collagen-induced arthritis of mice.   7th International Conference on Osteoporosis and Bone Research, 2014. Xiamen,   China. October 16-19, 2014 (Accepted).

3.         

Baosheng Guo, Aiping Lu, Baoting Zhang, Ge Zhang. Inhibition of miR-214 by (Asp-Ser-Ser)6-liposome   capsulated antagomiR-214 in osteogenic cells of aged osteoporotic rats: Quantification   analysis for expression levels of miR-214, osteocalcin mRNA and ATF4 protein in   osteogenic cells. 2014 American Orthopaedics Society Annual Meeting, New Orleans,   Louisiana March 15-18 (http://www.ors.org/Transactions/60/0604.pdf).

4.         

Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic silencing intra-osseous Plekho1   for promoting bone formation in a rat model of aged postmenopausal osteoporosis   (http://www.ors.org/Transactions/60/0566.pdf). 2014 American Orthopaedics Society   Annual Meeting, New Orleans, Louisiana March 15-18.

5.         

Baosheng Guo, Jin Liu, Heng Wu, Lingqiang Zhang, Ling   Qin, Aiping Lu, Baoting Zhang, Ge Zhang. Ckip-1 in osteoblasts plays an inhibition   role in bone formation in aged male osteoporosis. MOLECULAR THERAPY. Vol. 22.   Suppl.1 S39-S40. American Society of Gene & Cell Therapy 17th Annual Meeting.   Washingon, DC. May 21-24, 2014.

6.         

Baosheng Guo, Liu Jin, Dang lei, Liang Chao, Xiaohua   Pan, Lingqiang Zhang, Aiping Lu, Baoting Zhang,   Ge Zhang. Up-regulated CKIP-1 expression within   osteoblasts associates with reduced BMP signaling and decreased bone formation   during aging. 5th Sino-American Symposium on Clinical and Translational Medicine   (SAS-CTM). Beijing, China. June 21-22, 2014.

7.         

Baosheng Guo, Liu Jin, Heng Wu, Dang lei, Lingqiang   Zhang, Aiping Lu, Baoting Zhang,   Ge Zhang. Therapeutic silencing intra-osseous Ckip-1   for promoting bone formation in an aged rat model of male osteoporosis. ASBMR   2014 Annual Meeting. Houston, Texas. September 12-15, 2014.

8.         

Baosheng Guo, Liang Chao, Xiaohua Pan, Lingqiang Zhang,   Aiping Lu, Baoting Zhang, Ge Zhang. Up-regulated CKIP-1 expression within   osteoblasts associates with reduced BMP signaling and decreased bone formation   during aging. 7th International Conference on Osteoporosis and Bone Research,   2014. Xiamen, China. October 16-19, 2014 (Accepted).

9.         

Defang Li, Chao Liang, Baosheng Guo, Jin Liu, Lei Dang, Liang Xu, Xiaojuan He, Zicai Liang, Aiping Lu, Ge Zhang. DNM3 Participates in Exosome-Mediated   miR-214 Transfer From Differentiating Osteoclasts To Regulate Osteoblastic Activity:   In Vitro Evidences. MOLECULAR THERAPY. Vol. 22. Suppl.1 S158-S158. American Society   of Gene & Cell Therapy 17th Annual Meeting. Washingon, DC. May 21-24, 2014.

10.      

Defang Li, Chao Liang, Baosheng Guo, Jin Liu, Lei Dang, Liang Xu, Xiaojuan He, Zicai Liang, Aiping Lu, Ge Zhang. Exosome-encapsulated miR-214 secreted   from osteoclast to inhibit osteoblastic activity. ASBMR 2014 Annual Meeting. Houston,   Texas. September 12-15, 2014 (Accepted).

11.      

Biao Liu, Xiaojuan He, Ge Zhang, Aiping Lu. A novel triptolide-nucleolin aptamer conjugate (TMPC001) with super antitumor   activity on advanced pancreatic cancer. Planta Med 2014; 80 - CL26 DOI: 10.1055/s-0034-1382359.

12.      

Biao Liu, Baosheng Guo, Xiaojuan He, Defang Li , Ge Zhang, Aiping Lu. A novel Triptolide-Nucleolin aptamer conjugate with super antitumor activity   on advanced pancreatic cancer cell in vitro. MOLECULAR THERAPY. Vol. 22. Suppl.1   S221-S221. American Society of Gene & Cell Therapy 17th Annual Meeting. May   21-24, 2014.

13.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge Zhang. Aptamer-Functionalized Lipid Nanoparticles (LNPs) Targeting Osteoblasts as   a Novel RNA Interference-Based Bone Anabolic Strategy. ASBMR 2014 Annual Meeting.   Houston, Texas. September 12-15, 2014 (Accepted).

14.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge Zhang. Aptamer-Functionalized Lipid Nanoparticles (LNPs) Targeting Osteoblasts as   a Novel RNAi-Based Bone Anabolic Strategy. 5th Sino-American Symposium on Clinical   and Translational Medicine (SAS-CTM). Beijing, China. June 21-22, 2014.

15.      

Chao Liang, Baosheng Guo, Heng Wu, Lei Dang, Zhijun Yang, Lingqiang Zhang, Aiping Lu, Ge Zhang. Development of   aptamer-functionalized osteoblast-targeting lipid nanoparticles encapsulating   osteogenic siRNAs for bone anabolic therapy: investigation of tissue-selective   distribution, dose-response pattern and persistence of gene silencing. Orthopaedic   Research Society (ORS) 2014 annual meeting. March 15-18, 2014 (http://www.ors.org/Transactions/60/1160.pdf).  

16.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge Zhang. Aptamer-functionalized lipid nanoparticles   (LNPs) targeting osteoblasts as a novel RNA interference (RNAi)-based bone anabolic   strategy. The 7th International Conference on Osteoporosis and Bone Research (ICOBR   2014). October 16-19, 2014 (Accepted).

17.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge Zhang. Aptamer-functionalized delivery system for osteogenic siRNAs to achieve osteoblast-specific   RNA interference for bone anabolic therapy. Orthopaedic Research Society (ORS)   2015 annual meeting. Xiamen, China. March 28-31, 2015 (Submitted).

18.      

Lei Dang, Baosheng Guo, Defang Li, Aiping Lv, Ge Zhang. A delivery system specifically approaching bone resorption surfaces to facilitate   therapeutic modulation of miRNAs in osteoclasts. MOLECULAR THERAPY. Vol. 22. Suppl.1.   S131-S131. American Society of Gene & Cell Therapy (ASGCT) 2014 annual meeting,   Washington, USA. May 21-24, 2014.

19.      

Lei Dang, Baosheng Guo, Defang Li, Jin Liu, Chao Liang, Xiaojuan He, Heng Wu, Zhijun Yang, Zicai   Liang, Aiping lu, Ge Zhang. A peptide-modified   delivery system specifically approaching bone resorption surfaces for therapeutic   modulation of miRNAs in osteoclasts. American Society for Bone and Mineral Research   (ASMBR) 2014 annual meeting, Houston, USA, September 12-15, 2014.

20.      

Lei Dang, Baosheng Guo, Defang Li, Jin Liu, Chao Liang, Xiaojuan He, Heng Wu, Zhijun Yang, Zicai   Liang, Aiping lu, Ge Zhang. A delivery system   to approache bone resorption surfaces for specifically targeting osteoclasts in   vivo. Orthopaedic Research Society (ORS) 2015 annual meeting, Las Vegas, USA,   March 24-28, 2015 (Submitted).

21.      

Jun Lu, Biao Liu, Xiaojuan He, Jie Xu,   Aiping Lu, Ge Zhang.A novel method   for aptamer-triptolide conjugate linked by an acid-labile vinyl ether bond: synthesis,   characterization and pH-sensitive biological properties of the conjugate.University   Town campus of NUS, Singapore. December 14-17, 2014.

 

 

 

Published Conference Abstract in 2013

 

1.        

Baosheng Guo, Baoting Zhang, Jun Wang, Chao Liang,   Heng Wu, Zhijun Yang, Albert H. L. Chow, Zhibo Hou, Yadong Huang, Fuchu He, Ling   Qin, Lingqiang Zhang, Zhaoxiang Bian, Aiping Lu, Ge Zhang. (Asp-Ser-Ser)6 facilitates bone anabolic siRNA specifically   targeting osteogenic cells in aged ovariectomized rats. 2013 Orthopaedics Research   Society Annual Meeting. San Antonio, Texas. January 26–29, 2013 (http://www.ors.org/Transactions/59/PS2--082/1465.html).

2.        

Baosheng Guo, Xiaogang Wang,   An Hong, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic inhibition of miR-214 within osteogenic cells in aged osteoporotic   rats induced by ovariectomy for bone anabolic strategy: Optimization of dosage   and duration. Bone Joint J 2014 vol. 96-B no. SUPP 11. 8th Combined Meeting of   Orthopaedic Research Societies. San Servolo Venice, Italy. October 13-16, 2013.

3.        

Baosheng Guo, Xiaogang Wang, An Hong, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic silencing intra-osseous PLEKHO1   for promoting bone formation in a rat model of aged postmenopausal osteoporosis.   RNAi China, 2013. Kunshan, China. June 20-22, 2013.

4.        

Bing He, Jin Liu, Tao Tang, Baosheng Guo, Xiaohua Pan, Aiping Lu and Ge Zhang. Potential strategy   regulating miRNAs to improve impaired fracture healing in aged females: A systematic   view for timing and targets. Bone Joint J. 2014 vol. 96-B no. SUPP 11 207. 8h   Combined Meeting of Orthopaedic Research Societies. San Servolo Venice, Italy.   October 13-16, 2013.

5.        

Jin Liu, Baosheng Guo, Yixin He, Xiaohua Pan, Lei Dang, Lingqiang Zhang, Aiping Lu, Ge Zhang. Could casein kinase-2 interacting protein-1   (CKIP-1) be postulated as a molecular target for promoting aged fracture repair   in females? JOURNAL OF BONE AND MINERAL RESEARCH. Vol. 28. Suppl. 1. 2013 American   Society of Bone and Mineral Research Annual Meeting. Baltimore, Maryland, USA.   October 4–7, 2013.

 


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