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Current Projects

Project 1

Title: Therapeutic RNAi targeting CKIP-1 to reverse severe postmenopausal osteoporosis

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Hong Kong General Research Fund

Project ID: HKBU 479111

Exercise Year: 2011/2012

Approved Project Duration: 30 months

Project Fund: HK$ 920,000

Coordinator: Dr. Baosheng Guo (Ph.D.)

Project 2

Title: Toward an emerging paradigm of network medicine: An innovative platform to combinational herbs / compounds-based drug discovery for complex diseases

Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.)

Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University

Project ID: RC-IRMS/12-13/02

Exercise Year: 2012/2013

Approved Project Duration: 24 months

Project Fund: HK$ 3,000,000

Coordinator: Dr. Guang Zheng (Ph.D.)

Project 3

Title: Skeletal role of CK2-interating Protein-1 in Regulating Osteoblastic Bone Formation: Molecular Mechanism and Reversing Osteoporosis

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Research Grants Council & Natural Science Foundation Council

Project ID: N_HKBU435/12

Exercise Year: 2012/2013

Approved Project Duration: 48 months

Project Fund: HK$ 753,925

Coordinator: Dr. Baosheng Guo (Ph.D.)

Project 4

Title: Study on molecular mechanism of bone formation reduction in aged women: Functional role of CKIP-1

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Natural Science Foundation Council

Project ID: NSFC 81272045

Exercise Year: 2012/2013

Approved Project Duration: 36 months

Project Fund: RMB 700,000

Coordinator: Dr. Baosheng Guo (Ph.D.)

Project 5

Title: Toward a novel bone anabolic strategy for aged postmenopausal osteoporosis: Inhibiting miR-214 inosteogenic cells for promoting bone formation

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Hong Kong General Research Fund

Project ID: HKBU 478312

Exercise Year: 2012/2013

Approved Project Duration: 30 months

Project Fund: HK$ 950,000

Coordinator: Dr. Baosheng Guo (Ph.D.)

Project 6

Title: Development of aptamer-conjugated Triptolide specifically targeting synovial cell

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences (Contract Study)

Project ID: SCM-2012-CR-001

Exercise Year: 2012/2013

Approved Project Duration: N/A

Project Fund: RMB 500,000

Coordinator: Ms. Lei Dang (B.Sc.)

Project 7

Title: Screening on anti-rheumatic herbal medicines

Principal Investigator: Dr. Aiping Lu (M.D., Ph.D.)

Funding Body: Hong Kong Baptist University

Project ID: 33-12-903

Exercise Year: 2012/2013

Approved Project Duration: 24 months

Project Fund: HK$ 1,000,000

Coordinator: Dr. Cheng Lu (Ph.D.)

Project 8

Title: Does aberrantly overexpressed casein kinase-2 interacting protein-1 contribute to failure of osteoblast-mediated repair for bone erosion in rheumatoid arthritis?

Principal Investigator: Dr. Aiping Lu (M.D., Ph.D.)

Funding Body: Kunshan RNAi Institute (Contract Study)

Project ID: N/A

Exercise Year: 2013/2014

Approved Project Duration: 36 months

Project Fund: RMB 3,000,000

Coordinator: Dr. Xiaojuan He (M.D.)

Project 9

Title: Understanding the molecular mechanism in failure of osteoblast-mediated repair for articular bone erosion during progressive rheumatoid arthritis: Role of casein kinase-2 interacting protein-1 in controlling osteoblast function

Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.)

Funding Body: Research Grants Council

Project ID: HKBU 261113

Exercise Year: 2013/2014

Approved Project Duration: 24 months

Project Fund: HK$ 606,223

Coordinator: Dr. Xiaojuan He (M.D.)

Project 10

Title: Aptamer-functionalized Osteoblast-targeting Delivery System for Osteogenic siRNAs to Achieve Cell-specific RNA interference for Bone Anabolic Therapy

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Research Committee of Hong Kong Baptist University

Project ID: FRG2/12-13/027

Exercise Year: 2013/2014

Approved Project Duration: 24 months

Project Fund: HK$ 135,000

Coordinator: Mr. Chao Liang (M.S.)

Project 11

Title: Metabolomics Analysis of Chinese Medicine in Epidemic Encephalitis B prevention and treatment

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences (Contract Study)

Project ID: SCM-2013-CR-001

Exercise Year: 2013~

Approved Project Duration: N/A

Coordinator: Ms. Lei Dang (B.S.)

Project 12

Title: Establishing the bridge for translating cell-specific RNA interference to bone anabolic therapy: An aptamer-functionalized osteoblast-targeting delivery system for osteogenic siRNAs

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Science and Technology Innovation Commission of Shenzhen Municipality

Project ID: SCM-2013-SZTIC-001

Exercise Year: 2013/2014

Approved Project Duration: 24 months

Project Fund: RMB 300,000

Coordinator: Mr. Chao Liang (M.S.)

Project 13

Title: Research and development of triptolide-aptamer drug

Principal Investigator: Prof. AipingLu (M.D., Ph.D.)

Funding Body: National Science and Technology Major Projects for "major New Drugs Innovation and Development"

Project ID: 2013ZX09301307

Exercise Year: 2013/2015

Approved Project Duration: 36 months

Project Fund: RMB 1,500,000

Coordinator: Dr. Xiaojuan He (M.D.)

Project 14

Title: A unique platform for drug discovery of combinational drugs / Chinese herbal medicines / compounds

Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.)

Funding Body: Hong Kong Baptist University Strategic Development Fund

Project ID: SDF13-1209-P01

Exercise Year: 2014/2017

Approved Project Duration: 36 months

Project Fund: HK$ 3,000,000

Coordinator: Dr. Guang Zheng (Ph.D.)

Project 15

Title: Role of MiR-214 within Osteoclast in Regulating Osteoblastic Bone Formation

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Research Committee of Hong Kong Baptist University

Project ID: FRG2/13-14/006

Exercise Year: 2014/2016

Approved Project Duration: 24 months

Project Fund: HK$ 135,000

Coordinator: Dr. Defang Li (Ph.D.)

Project 16

Title: The Development of Chinese Medicine Clinical Practice Guidelines in Hong Kong

Principal Investigator: Prof. Aiping LU (M.D., Ph.D.) & Prof. Zhaoxiang BIAN (M.D., Ph.D.)

Funding Body: Hospital Authority

Project ID: HA 820/126/19/19/14/6/12/1

Exercise Year: 2013/2014

Approved Project Duration: 15 months

Project Fund: HK$ 444,320

Coordinator: Ms. Nannan Shi (M.Phil.)

Project 17

Title: Cell-specific Aptamer Facilitates Triptolide Selectively Targeting Fibroblast-like Synoviocytes and Specifically Reducing Exposure to Liver Cells

Principal Investigator: Prof. Aiping LU (M.D., Ph.D.)

Funding Body: Research Committee of Hong Kong Baptist University

Project ID: 30-12-286

Exercise Year: 2013/2014

Approved Project Duration: 18 months

Project Fund: HK$ 131,100

Coordinator: Dr. Cheng Lu (Ph.D.)

Project 18

Title: Role of miR-214 from Osteoclast in Regulating Osteoblastic Bone Formation

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University

Project ID: RC-IRMS/13-14/02

Exercise Year: 2014/2015

Approved Project Duration: 24 months

Project Fund: HK$ 2,981,576

Coordinator: Dr. Defang Li (Ph.D.)

Project 19

Title: Aptamer-functionalized osteoblast-targeting delivery system for osteogenic siRNAs to achieve cell-specific RNA interference for bone anabolic therapy

Principal Investigator: Dr. Ge Zhang (M.D.)

Funding Body: Hong Kong General Research Fund (GRF)

Project ID: 12102914

Exercise Year: 2014/2015

Approved Project Duration: 36 months

Project Fund: HK$ 1,035,000

Coordinator: Mr. Chao Liang (M.S.)

Project 20

Title: Characterization of Linkage between Symbiotic Gut Microbes and Fatty Acid Metabolism in Rheumatoid Arthritis Patients

Principal Investigator: Prof. Aiping LU (M.D., Ph.D.) & Prof. Cai Zongwei (Ph.D.)

Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University

Project ID: RC-IRMS/13-14/03

Exercise Year: 2014/2015

Approved Project Duration: 24 months

Project Fund: HK$ 2,944,160

Coordinator: Dr. Cheng Lv (Ph.D.)

Project 21

Title: Toward Targeted Therapy In Advanced Pancreatic Cancer: A Smart Triptolide-Nucleolin Aptamer Conjugate (UIM/256)

Principal Investigator: Prof. Aiping Lu

Funding Body: Hong Kong Innovation and Technology Fund

Project ID: 33-14-106

Exercise Year: 2014/2016

Approved Project Duration: 24 months

Project Fund: HK$ 2,339,560

Coordinator: Mr. Biao Liu (M.S.)

Project 22

Title: Toward Cell-targeted Therapeutics in Osteosarcoma: a Smart Triptolide-aptamer Conjugate

Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) and Prof. Dean Guo (Ph.D.)

Funding Body: Croucher Foundation

Project ID: Gnt#CAS14BU/CAS14201

Exercise Year: 2014/2016

Approved Project Duration: 36 months

Project Fund: HK$1,200,000

Coordinator: Dr. Defang Li (Ph.D.) and Mr. Chao Liang (M.S.)

Project 23

Title: Targeting a Critical Disease Biomarker - C Reactive Protein: A Combination Therapy Using Leflunomide and Ligustrazine in Rheumatoid Arthritis

Principal Investigator: Prof. Aiping LU (M.D., Ph.D.)

Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University

Project ID: RC-IRMS/14-15/02

Exercise Year: 2015/2016

Approved Project Duration: 24 months

Project Fund: HK$ 2,833,595

Coordinator: Dr. Cheng Lv (Ph.D.)

Project 24

Title: Development of an Integrative Model for Reconstructing Dynamic Transcriptional Regulatory Networks from High Throughput Data

Principal Investigator: Dr. Hailong Zhu (PhD)

Funding Body: Hong Kong General Research Fund

Project ID: HKBU 212613

Exercise Year: 2013/2014

Approved Project Duration: 36 months

Project Fund: HK$ 500,000

Coordinator: Dr. Winston P. Kuo (M.D.)

Project 25

Title: A Stage-varying Methodology That Can Reconstruct the Dynamic Gene Regulations during the Process of Cancer Progression from Stage-course Transcriptional Data

Principal Investigator: Dr. Hailong Zhu (PhD)

Funding Body: Hong Kong General Research Fund

Project ID: HKBU 212111

Exercise Year: 2011/2012

Approved Project Duration: 36 months

Project Fund: HK$ 922,500

Coordinator: Dr. Winston P. Kuo (M.D.), Prof. Stephen Kwok-wing Tsui

Project 26

Title: Computational Drug screening for Ebola virus infection using Traditional Chinese Medicine Database

Principal Investigator: Dr. Hailong Zhu (PhD)

Funding Body: Faculty Research Grant of Hong Kong Baptist University

Project ID: FRG2/14-15/063

Exercise Year: 2014/2015

Approved Project Duration: 12 months

Project Fund: HK$ 125,000

Project 27

Title: A Computational Framework of Modeling the Transcriptional Regulation in Single Cells

Principal Investigator: Principal Investigator: Dr. Hailong Zhu (PhD)

Funding Body: Faculty Research Grant of Hong Kong Baptist University

Project ID: FRG2/13-14/056

Exercise Year: 2013/2014

Approved Project Duration: 12 months

Project Fund: HK$ 127,000

Project 28

Title: Toward an emerging paradigm of network medicine: An innovative platform to combinational herbs / compounds-based drug discovery for complex diseases

Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.)

Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University

Project ID: RC-IRMS/12-13/02

Exercise Year: 2012/2013

Approved Project Duration: 24 months

Project Fund: HK$ 3,000,000

Coordinator: Dr. Guang Zheng (Ph.D.)

Project 29

Title: A simulation Study of Identifying the Transcriptional Regulatory Network

Principal Investigator: Principal Investigator: Dr. Hailong Zhu (PhD)

Funding Body: Faculty Research Grant of Hong Kong Baptist University

Project ID: FRG2/11-12/099

Exercise Year: 2011/2012

Approved Project Duration: 12 months

Project Fund: HK$ 65,000