Project 1 | Title: Therapeutic RNAi targeting CKIP-1 to reverse severe postmenopausal osteoporosis Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Hong Kong General Research Fund Project ID: HKBU 479111 Exercise Year: 2011/2012 Approved Project Duration: 30 months Project Fund: HK$ 920,000 Coordinator: Dr. Baosheng Guo (Ph.D.) |
Project 2 | Title: Toward an emerging paradigm of network medicine: An innovative platform to combinational herbs / compounds-based drug discovery for complex diseases Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University Project ID: RC-IRMS/12-13/02 Exercise Year: 2012/2013 Approved Project Duration: 24 months Project Fund: HK$ 3,000,000 Coordinator: Dr. Guang Zheng (Ph.D.) |
Project 3 | Title: Skeletal role of CK2-interating Protein-1 in Regulating Osteoblastic Bone Formation: Molecular Mechanism and Reversing Osteoporosis Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Research Grants Council & Natural Science Foundation Council Project ID: N_HKBU435/12 Exercise Year: 2012/2013 Approved Project Duration: 48 months Project Fund: HK$ 753,925 Coordinator: Dr. Baosheng Guo (Ph.D.) |
Project 4 | Title: Study on molecular mechanism of bone formation reduction in aged women: Functional role of CKIP-1 Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Natural Science Foundation Council Project ID: NSFC 81272045 Exercise Year: 2012/2013 Approved Project Duration: 36 months Project Fund: RMB 700,000 Coordinator: Dr. Baosheng Guo (Ph.D.) |
Project 5 | Title: Toward a novel bone anabolic strategy for aged postmenopausal osteoporosis: Inhibiting miR-214 inosteogenic cells for promoting bone formation Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Hong Kong General Research Fund Project ID: HKBU 478312 Exercise Year: 2012/2013 Approved Project Duration: 30 months Project Fund: HK$ 950,000 Coordinator: Dr. Baosheng Guo (Ph.D.) |
Project 6 | Title: Development of aptamer-conjugated Triptolide specifically targeting synovial cell Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences (Contract Study) Project ID: SCM-2012-CR-001 Exercise Year: 2012/2013 Approved Project Duration: N/A Project Fund: RMB 500,000 Coordinator: Ms. Lei Dang (B.Sc.) |
Project 7 | Title: Screening on anti-rheumatic herbal medicines Principal Investigator: Dr. Aiping Lu (M.D., Ph.D.) Funding Body: Hong Kong Baptist University Project ID: 33-12-903 Exercise Year: 2012/2013 Approved Project Duration: 24 months Project Fund: HK$ 1,000,000 Coordinator: Dr. Cheng Lu (Ph.D.) |
Project 8 | Title: Does aberrantly overexpressed casein kinase-2 interacting protein-1 contribute to failure of osteoblast-mediated repair for bone erosion in rheumatoid arthritis? Principal Investigator: Dr. Aiping Lu (M.D., Ph.D.) Funding Body: Kunshan RNAi Institute (Contract Study) Project ID: N/A Exercise Year: 2013/2014 Approved Project Duration: 36 months Project Fund: RMB 3,000,000 Coordinator: Dr. Xiaojuan He (M.D.) |
Project 9 | Title: Understanding the molecular mechanism in failure of osteoblast-mediated repair for articular bone erosion during progressive rheumatoid arthritis: Role of casein kinase-2 interacting protein-1 in controlling osteoblast function Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) Funding Body: Research Grants Council Project ID: HKBU 261113 Exercise Year: 2013/2014 Approved Project Duration: 24 months Project Fund: HK$ 606,223 Coordinator: Dr. Xiaojuan He (M.D.) |
Project 10 | Title: Aptamer-functionalized Osteoblast-targeting Delivery System for Osteogenic siRNAs to Achieve Cell-specific RNA interference for Bone Anabolic Therapy Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Research Committee of Hong Kong Baptist University Project ID: FRG2/12-13/027 Exercise Year: 2013/2014 Approved Project Duration: 24 months Project Fund: HK$ 135,000 Coordinator: Mr. Chao Liang (M.S.) |
Project 11 | Title: Metabolomics Analysis of Chinese Medicine in Epidemic Encephalitis B prevention and treatment Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences (Contract Study) Project ID: SCM-2013-CR-001 Exercise Year: 2013~ Approved Project Duration: N/A Project Fund: RMB 500,000 Coordinator: Ms. Lei Dang (B.S.) |
Project 12 | Title: Establishing the bridge for translating cell-specific RNA interference to bone anabolic therapy: An aptamer-functionalized osteoblast-targeting delivery system for osteogenic siRNAs Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Science and Technology Innovation Commission of Shenzhen Municipality Project ID: SCM-2013-SZTIC-001 Exercise Year: 2013/2014 Approved Project Duration: 24 months Project Fund: RMB 300,000 Coordinator: Mr. Chao Liang (M.S.) |
Project 13 | Title: Research and development of triptolide-aptamer drug Principal Investigator: Prof. AipingLu (M.D., Ph.D.) Funding Body: National Science and Technology Major Projects for "major New Drugs Innovation and Development" Project ID: 2013ZX09301307 Exercise Year: 2013/2015 Approved Project Duration: 36 months Project Fund: RMB 1,500,000 Coordinator: Dr. Xiaojuan He (M.D.) |
Project 14 | Title: A unique platform for drug discovery of combinational drugs / Chinese herbal medicines / compounds Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) Funding Body: Hong Kong Baptist University Strategic Development Fund Project ID: SDF13-1209-P01 Exercise Year: 2014/2017 Approved Project Duration: 36 months Project Fund: HK$ 3,000,000 Coordinator: Dr. Guang Zheng (Ph.D.) |
Project 15 | Title: Role of MiR-214 within Osteoclast in Regulating Osteoblastic Bone Formation Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Research Committee of Hong Kong Baptist University Project ID: FRG2/13-14/006 Exercise Year: 2014/2016 Approved Project Duration: 24 months Project Fund: HK$ 135,000 Coordinator: Dr. Defang Li (Ph.D.) |
Project 16 | Title: The Development of Chinese Medicine Clinical Practice Guidelines in Hong Kong Principal Investigator: Prof. Aiping LU (M.D., Ph.D.) & Prof. Zhaoxiang BIAN (M.D., Ph.D.) Funding Body: Hospital Authority Project ID: HA 820/126/19/19/14/6/12/1 Exercise Year: 2013/2014 Approved Project Duration: 15 months Project Fund: HK$ 444,320 Coordinator: Ms. Nannan Shi (M.Phil.) |
Project 17 | Title: Cell-specific Aptamer Facilitates Triptolide Selectively Targeting Fibroblast-like Synoviocytes and Specifically Reducing Exposure to Liver Cells Principal Investigator: Prof. Aiping LU (M.D., Ph.D.) Funding Body: Research Committee of Hong Kong Baptist University Project ID: 30-12-286 Exercise Year: 2013/2014 Approved Project Duration: 18 months Project Fund: HK$ 131,100 Coordinator: Dr. Cheng Lu (Ph.D.) |
Project 18 | Title: Role of miR-214 from Osteoclast in Regulating Osteoblastic Bone Formation Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University Project ID: RC-IRMS/13-14/02 Exercise Year: 2014/2015 Approved Project Duration: 24 months Project Fund: HK$ 2,981,576 Coordinator: Dr. Defang Li (Ph.D.) |
Project 19 | Title: Aptamer-functionalized osteoblast-targeting delivery system for osteogenic siRNAs to achieve cell-specific RNA interference for bone anabolic therapy Principal Investigator: Dr. Ge Zhang (M.D.) Funding Body: Hong Kong General Research Fund (GRF) Project ID: 12102914 Exercise Year: 2014/2015 Approved Project Duration: 36 months Project Fund: HK$ 1,035,000 Coordinator: Mr. Chao Liang (M.S.) |
Project 20 | Title: Characterization of Linkage between Symbiotic Gut Microbes and Fatty Acid Metabolism in Rheumatoid Arthritis Patients Principal Investigator: Prof. Aiping LU (M.D., Ph.D.) & Prof. Cai Zongwei (Ph.D.) Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University Project ID: RC-IRMS/13-14/03 Exercise Year: 2014/2015 Approved Project Duration: 24 months Project Fund: HK$ 2,944,160 Coordinator: Dr. Cheng Lv (Ph.D.) |
Project 21 | Title: Toward Targeted Therapy In Advanced Pancreatic Cancer: A Smart Triptolide-Nucleolin Aptamer Conjugate (UIM/256) Principal Investigator: Prof. Aiping Lu Funding Body: Hong Kong Innovation and Technology Fund Project ID: 33-14-106 Exercise Year: 2014/2016 Approved Project Duration: 24 months Project Fund: HK$ 2,339,560 Coordinator: Mr. Biao Liu (M.S.) |
Project 22 | Title:Toward Cell-targeted Therapeutics in Osteosarcoma: a Smart Triptolide-aptamer Conjugate Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) and Prof. Dean Guo (Ph.D.) Funding Body: Croucher Foundation Project ID: Gnt#CAS14BU/CAS14201 Exercise Year: 2014/2016 Approved Project Duration: 36 months Project Fund: HK$ 1,200,000 Coordinator: Dr. Defang Li (Ph.D.) and Mr. Chao Liang (M.S.) |
Project 23 | Title: Targeting a Critical Disease Biomarker - C Reactive Protein: A Combination Therapy Using Leflunomide and Ligustrazine in Rheumatoid Arthritis Principal Investigator: Prof. Aiping LU (M.D., Ph.D.) Funding Body: Interdisciplinary Research Matching Scheme (IRMS) of Hong Kong Baptist University Project ID: RC-IRMS/14-15/02 Exercise Year: 2015/2016 Approved Project Duration: 24 months Project Fund: HK$ 2,833,595 Coordinator: Dr. Cheng Lv (Ph.D.) |
Project 24 | Title: Development of an Integrative Model for Reconstructing Dynamic Transcriptional Regulatory Networks from High Throughput Data Principal Investigator: Dr. Hailong Zhu (PhD) Funding Body: Hong Kong General Research Fund Project ID: HKBU 212613 Exercise Year: 2013/2014 Approved Project Duration: 36 months Project Fund: HK$ 500,000 Coordinator: Dr. Winston P. Kuo (M.D.) |
Project 25 | Title: A Stage-varying Methodology That Can Reconstruct the Dynamic Gene Regulations during the Process of Cancer Progression from Stage-course Transcriptional Data Principal Investigator: Dr. Hailong Zhu (PhD) Funding Body: Hong Kong General Research Fund Project ID: HKBU 212111 Exercise Year: 2011/2012 Approved Project Duration: 36 months Project Fund: HK$ 922,500 Coordinator: Dr. Winston P. Kuo (M.D.), Prof. Stephen Kwok-wing Tsui |
Project 26 | Title: Computational Drug screening for Ebola virus infection using Traditional Chinese Medicine Database Principal Investigator: Dr. Hailong Zhu (PhD) Funding Body: Faculty Research Grant of Hong Kong Baptist University Project ID: FRG2/14-15/063 Exercise Year: 2014/2015 Approved Project Duration: 12 months Project Fund: HK$ 125,000 |
Project 27 | Title: A Computational Framework of Modeling the Transcriptional Regulation in Single Cells Principal Investigator: Dr. Hailong Zhu (PhD) Funding Body: Faculty Research Grant of Hong Kong Baptist University Project ID: FRG2/13-14/056 Exercise Year: 2013/2014 Approved Project Duration: 12 months Project Fund: HK$ 127,000 |
Project 28 | Title: A pilot study of modelling the dynamic gene regulation during the developmental cycle of human malaria parasite Principal Investigator: Dr. Hailong Zhu (PhD) Funding Body: Faculty Research Grant of Hong Kong Baptist University Project ID: FRG2/12-13/061 Exercise Year: 2012/2013 Approved Project Duration: 12 months Project Fund: HK$ 135,000 |
Project 29 | Title: A simulation Study of Identifying the Transcriptional Regulatory Network Principal Investigator: Dr. Hailong Zhu (PhD) Funding Body: Faculty Research Grant of Hong Kong Baptist University Project ID: FRG2/11-12/099 Exercise Year: 2011/2012 Approved Project Duration: 12 months Project Fund: HK$ 65,000 |
