March 01, 2015
Recently, a collaborative research done by PhD student Mr. Jin Liu, MPhil student Miss. Lei Dang and Post-doctoral fellow Defang Li in IBTS was published in “Biomaterials” (Journal Impact Factors: 8.312). The work named “A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts”. In this study, they developed an osteoclast-targeting delivery system, i.e. (D-Asp8)-Liposome, to facilitate miRNA modulators specifically approaching bone-resorption surfaces to selectively target osteoclast to regulate osteoclast function. It would provide a promising osteoclast-targeting delivery system to facilitate clinical translation of miRNA modulators in treating osteoclast-dysfunction-induced skeletal diseases.